Molecular mechanisms of two-component signal transduction

CP Zschiedrich, V Keidel, H Szurmant - Journal of molecular biology, 2016 - Elsevier
Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …

Ser/Thr phosphorylation as a regulatory mechanism in bacteria

J Dworkin - Current opinion in microbiology, 2015 - Elsevier
Highlights•Ser/Thr phosphorylation is involved in the regulation of cell wall synthesis and
translation.•Ser/Thr kinases phosphorylate elements of two-component systems.•Ser/Thr …

[HTML][HTML] MtrA modulates Mycobacterium tuberculosis cell division in host microenvironments to mediate intrinsic resistance and drug tolerance

EJR Peterson, AN Brooks, DJ Reiss, A Kaur, J Do… - Cell Reports, 2023 - cell.com
The success of Mycobacterium tuberculosis (Mtb) is largely attributed to its ability to
physiologically adapt and withstand diverse localized stresses within host …

Regulation of competence for natural transformation in streptococci

L Fontaine, A Wahl, M Fléchard, J Mignolet… - Infection, Genetics and …, 2015 - Elsevier
Natural DNA transformation is a lateral gene transfer mechanism during which bacteria take
up naked DNA from their environment and stably integrate it in their genome. The proteins …

Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes

AR Flores, J Galloway-Peña… - Proceedings of the …, 2015 - National Acad Sciences
The molecular mechanisms underlying pathogen emergence in humans is a critical but
poorly understood area of microbiologic investigation. Serotype V group B Streptococcus …

[HTML][HTML] The Eukaryotic-Like Ser/Thr Kinase PrkC Regulates the Essential WalRK Two-Component System in Bacillus subtilis

EA Libby, LA Goss, J Dworkin - PLoS genetics, 2015 - journals.plos.org
Most bacteria contain both eukaryotic-like Ser/Thr kinases (eSTKs) and eukaryotic-like
Ser/Thr phosphatases (eSTPs). Their role in bacterial physiology is not currently well …

[HTML][HTML] A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis

J Tang, M Guo, M Chen, B Xu, T Ran, W Wang… - Nature …, 2023 - nature.com
Synthesis of capsular polysaccharide (CPS), an important virulence factor of pathogenic
bacteria, is modulated by the CpsBCD phosphoregulatory system in Streptococcus …

Two-component signal transduction systems in oral bacteria

RO Mattos-Graner, MJ Duncan - Journal of oral microbiology, 2017 - Taylor & Francis
We present an overview of how members of the oral microbiota respond to their environment
by regulating gene expression through two-component signal transduction systems (TCSs) …

Importance of protein Ser/Thr/Tyr phosphorylation for bacterial pathogenesis

J Bonne Køhler, C Jers, M Senissar, L Shi… - FEBS …, 2020 - Wiley Online Library
Protein phosphorylation regulates a large variety of biological processes in all living cells. In
pathogenic bacteria, the study of serine, threonine, and tyrosine (Ser/Thr/Tyr) …

To∼ P or Not to∼ P? Non‐canonical activation by two‐component response regulators

SK Desai, LJ Kenney - Molecular Microbiology, 2017 - Wiley Online Library
Bacteria sense and respond to their environment through the use of two‐component
regulatory systems. The ability to adapt to a wide range of environmental stresses is directly …