Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at
the cell cortex or in association with other cytoskeletal proteins, such as actin or …

Septins are cytoskeletal proteins that assemble into hetero-oligomeric complexes and sense
micron-scale membrane curvature. During infection with Shigella flexneri, an invasive …

Pyroptosis, a regulated form of pro-inflammatory cell death, is characterised by cell lysis and
by the release of cytokines, damage-and pathogen-associated molecular patterns. It plays …

Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent.
Although S. aureus and humans may have co‐evolved to the point of commensalism, the …

Motor proteins are key players in exerting spatiotemporal control over the intracellular
location of membrane-bound compartments, including endosomes containing cargo. In this …

Shigella flexneri is a Gram-negative bacterium causing severe bloody dysentery. Its
pathogenesis is largely dictated by a plasmid-encoded type III secretion system (T3SS) and …

In order to form functional filaments, human septins must assemble into hetero-oligomeric
rod-like particles which polymerize end-to-end. The rules governing the assembly of these …

During host cell invasion, Shigella escapes to the cytosol and polymerizes actin for cell-to-
cell spread. To restrict cell-to-cell spread, host cells employ cell-autonomous immune …