Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia
Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and …
be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and …
Effects of perinatal exposure to ketamine on the developing brain
Initially used as an analgesic and anesthetic, ketamine has unfortunately been abused as a
popular recreational party drug due to its psychotropic effects. Over the last decade …
popular recreational party drug due to its psychotropic effects. Over the last decade …
Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic …
Geraniol is an acyclic isoprenoid monoterpenoid analogue that has been shown to elicit
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …
Reversal and preventive pleiotropic mechanisms involved in the antipsychotic-like effect of taurine, an essential β-amino acid in ketamine-induced experimental …
Schizophrenia is a life disabling, multisystem neuropsychiatric disease mostly derived from
complex epigenetic-mediated neurobiological changes causing behavioural deficits …
complex epigenetic-mediated neurobiological changes causing behavioural deficits …
Role of MAPK/NF-κB pathway in cardioprotective effect of Morin in isoproterenol induced myocardial injury in rats
VK Verma, S Malik, SP Narayanan, E Mutneja… - Molecular biology …, 2019 - Springer
Oxidative stress plays a major role in myocardial injury. Morin, a bioflavonoid has known to
possess various biological activities in previous studies. Hence, this study evaluated the …
possess various biological activities in previous studies. Hence, this study evaluated the …
[HTML][HTML] Kolaviron abates busulfan-induced episodic memory deficit and testicular dysfunction in rats: the implications for neuroendopathobiological changes during …
Busulfan is a popular antileukemia chemotherapeutic alkylating agent widely known to
induce variety of serious adverse effects including chemobrain-related cognitive …
induce variety of serious adverse effects including chemobrain-related cognitive …
Lipopolysaccharide exacerbates ketamine-induced psychotic-like behavior, oxidative stress, and neuroinflammation in mice: ameliorative effect of diosmin
Schizophrenia, a neuropsychiatric disorder has been associated with aberrant
neurotransmission affecting behaviors, social preference, and cognition. Limitations in …
neurotransmission affecting behaviors, social preference, and cognition. Limitations in …
Mechanisms underpinning Carpolobia lutea G. Don ethanol extract's neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of …
Ethnopharmacological relevance Persistent ketamine insults to the central nervous system
block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and …
block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and …
Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia
Neuroinflammation plays a prominent role in the pathophysiology and progression of
schizophrenia. Thus, suppression of neuroinflammation may retard the progression of the …
schizophrenia. Thus, suppression of neuroinflammation may retard the progression of the …
[HTML][HTML] Antipsychotic effect of diosgenin in ketamine-induced murine model of schizophrenia: Involvement of oxidative stress and cholinergic transmission
B Ben-Azu, OG Adebayo, AR Fokoua… - IBRO Neuroscience …, 2024 - Elsevier
A decrease in the levels of antioxidant arsenals exacerbate generation of reactive
oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on …
oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on …