Abstract BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis.
They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as …

The endoplasmic reticulum (ER) is the cellular site of newly synthesized secretory and
membrane proteins. Such proteins must be properly folded and posttranslationally modified …

Drug resistance remains a critical problem in the treatment of patients with multiple
myeloma. Recent studies have de-termined that Notch signaling plays a major role in bone …

Apoptosis is a type of programmed cell death that produces changes in cell morphology and
in biochemical intracellular processes without inflammatory reactions. The components of …

Defects in apoptosis signaling contribute to poor outcome in pediatric acute lymphoblastic
leukemia (ALL), and overexpression of antiapoptotic Bcl-2 (Bcl-2 and Bcl-XL) family proteins …

Pemetrexed, a folate antimetabolite, combined with cisplatin is used as a first-line therapy for
malignant pleural mesothelioma (MPM) and locally advanced or metastatic non-small-cell …

Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. In recent
years, these ecosystems have become affected through anthropogenic activities. The …

Canonical Wnt signaling has been implicated in the regulation of multiple myeloma (MM)
growth. Here, we investigated whether the targeting of this pathway with a novel …

Background A number of studies have implicated the direct involvement of the liver in
dengue virus (DENV) infection, and it has been widely shown that liver cells subsequently …

Monocytic cells are believed to be an important mediator of the pathology of dengue disease
in cases of secondary infection where pre-existing antibodies from a first infection facilitate …