Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …

Cancer is a leading cause of death in both developing and developed countries. With the
increase in the average global life expectancy, it has become a major health problem and …

Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …

Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …

The human race has survived many epidemics and pandemics that have emerged and
reemerged throughout history. The novel coronavirus Severe Acute Respiratory Syndrome …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Cancer drug resistance poses a significant obstacle to successful chemotherapy, primarily
driven by the activity of ATP‐binding cassette (ABC) transporters, which actively efflux …

Multidrug resistance (MDR) hinders treatment efficacy in cancer therapy. One typical
mechanism contributing to MDR is the overexpression of permeability-glycoprotein (P-gp) …

A supramolecular nanoprodrug based on the host–guest complexation of water-soluble
pillar [5] arene (WP5) and a boronate ester linked curcumin (Cur) was constructed, which …