Curcumin and its derivatives as potential therapeutic agents in prostate, colon and breast cancers

Z Mbese, V Khwaza, BA Aderibigbe - Molecules, 2019 - mdpi.com
Cancer is a life-threatening disease and is the second leading cause of death around the
world. The increasing threats of drug-resistant cancers indicate that there is an urgent need …

Developments in the anticancer activity of structurally modified curcumin: An up-to-date review

FC Rodrigues, NVA Kumar, G Thakur - European journal of medicinal …, 2019 - Elsevier
Curcumin is a pharmacologically active polyphenol derived from the popular spice element-
Turmeric. The therapeutic activity of curcumin has been extensively investigated over the …

Mechanism insights of curcumin and its analogues in cancer: An update

P Joshi, K Verma, D Kumar Semwal… - Phytotherapy …, 2023 - Wiley Online Library
Cancer is the world's second leading cause of mortality and one of the major public health
problems. Cancer incidence and mortality rates remain high despite the great …

Beyond the paclitaxel and vinca alkaloids: Next generation of plant-derived microtubule-targeting agents with potential anticancer activity

D Zhang, A Kanakkanthara - Cancers, 2020 - mdpi.com
Plants are an important source of chemically diverse natural products that target
microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel …

Recent advances of analogues of curcumin for treatment of cancer

S Zhao, C Pi, Y Ye, L Zhao, Y Wei - European Journal of Medicinal …, 2019 - Elsevier
Curcumin (CU), an edible natural pigment from Curcuma Longa, has demonstrated
extensive anti-tumor effect in vivo and in vitro. With the property of reversing drug resistance …

Antiproliferative activity of crocin involves targeting of microtubules in breast cancer cells

RR Hire, S Srivastava, MB Davis, A Kumar Konreddy… - Scientific reports, 2017 - nature.com
Crocin, a component of saffron spice, is known to have an anticancer activity. However, the
targets of crocin are not known. In this study, crocin was found to inhibit the proliferation of …

C1 inhibits liquid–liquid phase separation and oligomerization of tau and protects Neuroblastoma cells against toxic tau oligomers

A Pradhan, S Mishra, A Surolia… - ACS Chemical …, 2021 - ACS Publications
The pathological aggregation of tau is one of the major contributing factors for several
neurodegenerative tauopathies, including Alzheimer's disease. Here, we report that C1, a …

Recent advances of curcumin derivatives in breast cancer

Y Yin, Y Tan, X Wei, X Li, H Chen, Z Yang… - Chemistry & …, 2022 - Wiley Online Library
Curcumin is a potential plant‐derived drug for the treatment of breast cancer. Poor solubility
and bioavailability are the main factors that limit its clinical application. Various structural …

Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics

AS Girgis, P D'Arcy, DR Aboshouk, MS Bekheit - RSC advances, 2022 - pubs.rsc.org
The broad spectrum of curcumin's beneficial properties has encouraged medicinal
researchers to investigate its therapeutic efficacy against diverse diseases. The clinical …

A review of recent curcumin analogues and their antioxidant, anti-inflammatory, and anticancer activities

K Kaur, AK Al-Khazaleh, DJ Bhuyan, F Li, CG Li - Antioxidants, 2024 - mdpi.com
Curcumin, as the main active component of turmeric (Curcuma longa), has been
demonstrated with various bioactivities. However, its potential therapeutic applications are …