Regulation and function of AMPK in physiology and diseases

SM Jeon - Experimental & molecular medicine, 2016 - nature.com
adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily
conserved serine/threonine kinase that was originally identified as the key player in …

The role of AMPK in cancer metabolism and its impact on the immunomodulation of the tumor microenvironment

CK Keerthana, TP Rayginia, SC Shifana… - Frontiers in …, 2023 - frontiersin.org
Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that
is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse …

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

Y Zhao, X Hu, Y Liu, S Dong, Z Wen, W He, S Zhang… - Molecular cancer, 2017 - Springer
Cancer cells are frequently confronted with metabolic stress in tumor microenvironments
due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death …

ABC transporters in cancer stem cells: beyond chemoresistance

RR Begicevic, M Falasca - International journal of molecular sciences, 2017 - mdpi.com
The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of
the major obstacles to overcome in achieving lasting remission and a definitive cure in …

AMPK, mitochondrial function, and cardiovascular disease

S Wu, MH Zou - International journal of molecular sciences, 2020 - mdpi.com
Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis

A Sharma, SK Anand, N Singh, UN Dwivedi… - Experimental cell …, 2023 - Elsevier
Cells are programmed to favorably respond towards the nutrient availability by adapting
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …

The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics

DP Panigrahi, PP Praharaj, CS Bhol… - Seminars in cancer …, 2020 - Elsevier
Mitophagy is an evolutionarily conserved cellular process which selectively eliminates
dysfunctional mitochondria by targeting them to the autophagosome for degradation …

Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators

E Piccinin, G Villani, A Moschetta - Nature reviews Gastroenterology & …, 2019 - nature.com
Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …

AMPK, metabolism, and vascular function

C Rodríguez, M Muñoz, C Contreras… - The FEBS …, 2021 - Wiley Online Library
Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …

Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis

B Chaube, KM Citrin, M Sahraei, AK Singh… - Nature …, 2023 - nature.com
Abstract Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic
functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic …