Drug repurposing is an interesting field in the drug discovery scope because of reducing time and cost. It is also considered as an appropriate method for finding medications for …
Objective To describe rates and risk factors for prolonged postoperative use of opioids in patients who had not previously used opioids and undergoing major elective surgery …
A Alam, T Gomes, H Zheng, MM Mamdani… - Archives of internal …, 2012 - jamanetwork.com
Background This study evaluated the risk of long-term analgesic use after low-risk surgery in older adults not previously prescribed analgesics. Methods We conducted a retrospective …
DN Juurlink, MM Mamdani, DS Lee… - … England Journal of …, 2004 - Mass Medical Soc
Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that spironolactone significantly improves outcomes in patients with severe heart failure. Use of …
WP Wodchis, K Bushmeneva, M Nikitovic, I McKillop - 2013 - hspn.ca
Understanding how healthcare dollars are spent and attributing healthcare spending to individuals is an important activity for accountability and comparative performance …
Background—Current observational studies on warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation (AF) undergoing dialysis found conflicting results …
IC Lega, SE Bronskill, MA Campitelli… - Diabetes, Obesity …, 2019 - Wiley Online Library
Aims The objective of the study was to quantify the association between SGLT2 inhibitors and genital mycotic infection and between SGLT2 inhibitors and urinary tract infection (UTI) …
Background and Purpose: Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke associated with significant morbidity and mortality. Recent epidemiological …
LY Park-Wyllie, MM Mamdani, DN Juurlink, GA Hawker… - Jama, 2011 - jamanetwork.com
Context Osteoporosis is associated with significant morbidity and mortality. Oral bisphosphonates have become a mainstay of treatment, but concerns have emerged that …