Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

The mitogen-activated protein kinases (MAPKs) are a family of serine/threonine kinases that
play an essential role in signal transduction by modulating gene transcription in the nucleus …

The JNK proteins are activated by multiple and diverse stimuli, leading to varied and
seemingly contradictory cellular responses. In particular, JNKs have been reported to have a …

The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …

Experimental evidence supported by epidemiological findings suggests that solar ultraviolet
(UV) irradiation is the most important environmental carcinogen leading to the development …

Overwhelming) are a set of key stress-responsive kinases that mediate cell apoptosis, which
is an important process for tumor suppression. However, JNKs have also been implicated in …

La stimulation de la voie de transduction de signal Ras-MAPK (mitogen activated protein
kinase) résulte en une multitude d'événements incluant l'expression des gènes précoces …

Signaling pathways involve cascades of protein phosphorylation and ultimately affect
regulation of transcription in the nucleus. However, most of the kinases in these pathways …

Chronic ethanol abuse is associated with liver injury, neurotoxicity, hypertension,
cardiomyopathy, modulation of immune responses and increased risk for cancer, whereas …

Previous studies have shown that c-Jun NH2-terminal kinase (JNK) belongs to the mitogen-
activated protein kinase (MAPK) family of signal transduction components that are rapidly …