Biomimetic chromatography—A novel application of the chromatographic principles
KL Valko - Analytical Science Advances, 2022 - Wiley Online Library
Biomimetic chromatography is the name of the High Performance Liquid Chromatography
(HPLC) methods that apply stationary phases containing proteins and phospholipids that …
(HPLC) methods that apply stationary phases containing proteins and phospholipids that …
A comprehensive biophysical and theoretical study on the binding of dexlansoprazole with human serum albumin
Pharmacokinetics, pharmacodynamics, and therapeutic activity of drugs are defined by the
affinities between the drug and biological macromolecules through molecular recognition …
affinities between the drug and biological macromolecules through molecular recognition …
Modification of gradient HPLC method for determination of small molecules' affinity to human serum albumin under column safety conditions: Robustness and …
M Woziński, KE Greber, M Pastewska… - … of Pharmaceutical and …, 2024 - Elsevier
In the early stages of drug discovery, beyond the biological activity screening, determining
the physicochemical properties that affect the distribution of molecules in the human body is …
the physicochemical properties that affect the distribution of molecules in the human body is …
Steady-state and 3D fluorescence study reveals the binding of a dicoumarol analogue in subdomain IIA of human serum albumin with structural variation
Drugs exhibit pharmacological properties through their binding interactions with the target
receptors. Coumarins and dicoumarols are known to exhibit diverse pharmacological …
receptors. Coumarins and dicoumarols are known to exhibit diverse pharmacological …
Accessing lipophilicity and biomimetic chromatography profile of biologically active ingredients of botanicals used in the treatment of inflammatory bowel disease
In the present study, various procedures have been compared for the determination of
lipophilicity, hydrophobicity, and plasma protein binding of curcuminoids, boswellic acids …
lipophilicity, hydrophobicity, and plasma protein binding of curcuminoids, boswellic acids …
[HTML][HTML] Antimicrobial Evaluation of Two Polycyclic Polyprenylated Acylphloroglucinol Compounds: PPAP23 and PPAP53
AV Ammanath, M Matsuo, H Wang, F Kraus… - International Journal of …, 2024 - mdpi.com
Polycyclic polyprenylated acylphloroglucinols (PPAPs) comprise a large group of
compounds of mostly plant origin. The best-known compound is hyperforin from St. John's …
compounds of mostly plant origin. The best-known compound is hyperforin from St. John's …
Synthesis and structural elucidation of a unique turn-off fluorescent sensor based on oxo-bridged tin (IV) cluster for selective detection of dopamine in biological fluids
An oxo-bridged Sn (IV) Cluster,(TOC) was synthesized and fully characterized by FT-IR, UV–
vis, 1 H NMR, 119 Sn NMR, Mass spectrometry and single crystal X-ray diffraction studies …
vis, 1 H NMR, 119 Sn NMR, Mass spectrometry and single crystal X-ray diffraction studies …
Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis …
X Luo, Z Zhang, R Mu, G Hu, L Liu, X Liu - Pharmaceutics, 2024 - mdpi.com
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients
or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically …
or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically …
An improved workflow for the development of MS-compatible liquid chromatography assay purity and purification methods by using automated LC Screening …
J Manheim, AN Singh, P Aggarwal, FN Aldine… - Analytical and …, 2024 - Springer
The development of liquid chromatography UV and mass spectrometry (LC-UV–MS) assays
in pharmaceutical analysis is pivotal to improve quality control by providing critical …
in pharmaceutical analysis is pivotal to improve quality control by providing critical …