Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

Background Sunitinib resistance can be classified into primary and secondary resistance.
While accumulating research has indicated several underlying factors contributing to …

Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in
mediating antitumor responses to immune checkpoint inhibition is unknown. Here we show …

The global pandemic of sarcopenia, skeletal muscle loss and weakness, which prevails in
up to 50% of older adults is increasing worldwide due to the expansion of aging populations …

Prosurvival tumor necrosis factor receptor (TNFR) superfamily (TNFRSF) members on T
cells, including 4-1BB, CD27, GITR, and OX40, support T cell accumulation during clonal …

Background Severe, steroid-resistant asthma (SSRA) is a serious clinical problem in asthma
management. Affected patients have severe clinical symptoms, worsened quality of life, and …

The astronomical increase of the world's aged population is associated with the increased
prevalence of neurodegenerative diseases, heightened disability, and extremely high costs …

Abstract N6-methyladenosine (m6A), an internal modification in mRNA, plays a critical role
in regulating gene expression. Dysregulation of m6A modifiers promotes oncogenesis …