Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor
B Jena, G Dotti, LJN Cooper - Blood, The Journal of the …, 2010 - ashpublications.org
Infusions of antigen-specific T cells have yielded therapeutic responses in patients with
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …
Human cytomegalovirus immunity and immune evasion
SE Jackson, GM Mason, MR Wills - Virus research, 2011 - Elsevier
Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …
Cellular immune correlates of protection against symptomatic pandemic influenza
S Sridhar, S Begom, A Bermingham, K Hoschler… - Nature medicine, 2013 - nature.com
The role of T cells in mediating heterosubtypic protection against natural influenza illness in
humans is uncertain. The 2009 H1N1 pandemic (pH1N1) provided a unique natural …
humans is uncertain. The 2009 H1N1 pandemic (pH1N1) provided a unique natural …
First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody
With most of the T cells residing in the tissue, not the blood, developing noninvasive
methods for in vivo quantification of their biodistribution and kinetics is important for studying …
methods for in vivo quantification of their biodistribution and kinetics is important for studying …
One naive T cell, multiple fates in CD8+ T cell differentiation
The mechanism by which the immune system produces effector and memory T cells is
largely unclear. To allow a large-scale assessment of the development of single naive T …
largely unclear. To allow a large-scale assessment of the development of single naive T …
The T-cell response to Epstein-Barr virus–new tricks from an old dog
Epstein-Barr virus (EBV) infects most people and establishes life-long infection controlled by
the host's immune system. The genetic stability of the virus, deep understanding of the viral …
the host's immune system. The genetic stability of the virus, deep understanding of the viral …
Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection
T cell responses to viruses are initiated and maintained in tissue sites; however, knowledge
of human antiviral T cells is largely derived from blood. Cytomegalovirus (CMV) persists in …
of human antiviral T cells is largely derived from blood. Cytomegalovirus (CMV) persists in …
Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory
A Okhrimenko, JR Grün, K Westendorf… - Proceedings of the …, 2014 - National Acad Sciences
In the bone marrow, a population of memory T cells has been described that promotes
efficient secondary immune responses and has been considered to be preactivated, owing …
efficient secondary immune responses and has been considered to be preactivated, owing …
Local heroes or villains: tissue-resident memory T cells in human health and disease
Tissue-resident memory T (TRM) cells are increasingly associated with the outcomes of
health and disease. TRM cells can mediate local immune protection against infections and …
health and disease. TRM cells can mediate local immune protection against infections and …
[HTML][HTML] Properties of end-stage human T cells defined by CD45RA re-expression
SM Henson, NE Riddell, AN Akbar - Current opinion in immunology, 2012 - Elsevier
Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation
of highly differentiated CD45RA re-expressing memory T cells. These cells increase during …
of highly differentiated CD45RA re-expressing memory T cells. These cells increase during …