Impacts of bioinformatics to medicinal chemistry
KC Chou - Medicinal chemistry, 2015 - ingentaconnect.com
Facing the explosive growth of biological sequence data, such as those of protein/peptide
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …
An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
[HTML][HTML] iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC
Abstract N 6-methyladenine (6mA) is one kind of post-replication modification (PTM or
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
[HTML][HTML] iACP: a sequence-based tool for identifying anticancer peptides
Cancer remains a major killer worldwide. Traditional methods of cancer treatment are
expensive and have some deleterious side effects on normal cells. Fortunately, the …
expensive and have some deleterious side effects on normal cells. Fortunately, the …
PathogenFinder-distinguishing friend from foe using bacterial whole genome sequence data
Although the majority of bacteria are harmless or even beneficial to their host, others are
highly virulent and can cause serious diseases, and even death. Due to the constantly …
highly virulent and can cause serious diseases, and even death. Due to the constantly …
iRNA-Methyl: Identifying N6-methyladenosine sites using pseudo nucleotide composition
Occurring at adenine (A) with the consensus motif GAC, N 6-methyladenosine (m 6 A) is one
of the most abundant modifications in RNA, which plays very important roles in many …
of the most abundant modifications in RNA, which plays very important roles in many …
iRSpot-PseDNC: identify recombination spots with pseudo dinucleotide composition
Meiotic recombination is an important biological process. As a main driving force of
evolution, recombination provides natural new combinations of genetic variations. Rather …
evolution, recombination provides natural new combinations of genetic variations. Rather …
iAMP-2L: a two-level multi-label classifier for identifying antimicrobial peptides and their functional types
Antimicrobial peptides (AMPs), also called host defense peptides, are an evolutionarily
conserved component of the innate immune response and are found among all classes of …
conserved component of the innate immune response and are found among all classes of …
PseKNC: a flexible web server for generating pseudo K-tuple nucleotide composition
The pseudo oligonucleotide composition, or pseudo K-tuple nucleotide composition
(PseKNC), can be used to represent a DNA or RNA sequence with a discrete model or …
(PseKNC), can be used to represent a DNA or RNA sequence with a discrete model or …
Pseudo nucleotide composition or PseKNC: an effective formulation for analyzing genomic sequences
With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent
to develop automated methods for analyzing the relationship between the sequences and …
to develop automated methods for analyzing the relationship between the sequences and …