Over the recent years the wider availability and application of state-of-the-art immunological
technologies greatly advanced the insight into the mechanisms that play an important role in …

The incomplete removal of T cells that are reactive against self-proteins during their
differentiation in the thymus requires mechanisms of tolerance that prevent their effector …

Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted
at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy …

The cellular immune system, which is a critical component of human immunity, uses T cell
receptors (TCRs) to recognize antigenic proteins in the form of peptides presented by major …

Understanding the mechanisms of T cell antigen recognition that underpin adaptive immune
responses is critical for developing vaccines, immunotherapies and treatments against …

The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of
genes in the major histocompatibility complex whose name goes back to its discovery in …

Inflammatory diseases are often chronic and recurrent, and current treatments do not
typically remove underlying disease drivers. T cells participate in a wide range of …

Recognition of antigens by T cell receptors (TCRs) is a key component of adaptive immunity.
Understanding the structures of these TCR interactions provides major insights into immune …

Abstract Purpose of Review To commemorate the 50th anniversary of the groundbreaking
discovery of a remarkably strong association between HLA-B* 27 and ankylosing spondylitis …

Motivation T cells play an essential role in adaptive immune system to fight pathogens and
cancer but may also give rise to autoimmune diseases. The recognition of a peptide–MHC …