Cellular immune responses in the pathophysiology of preeclampsia

D Miller, K Motomura, J Galaz… - Journal of Leukocyte …, 2022 - academic.oup.com
Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at
20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality …

Sex differences in innate and adaptive immunity impact fetal, placental, and maternal health

KJ Baines, RC West - Biology of reproduction, 2023 - academic.oup.com
The differences between males and females begin shortly after birth, continue throughout
prenatal development, and eventually extend into childhood and adult life. Male embryos …

The central role of natural killer cells in preeclampsia

X Wei, X Yang - Frontiers in Immunology, 2023 - frontiersin.org
Preeclampsia (PE) is a disease that is unique to pregnancy and affects multiple systems. It
can lead to maternal and perinatal mortality. The precise etiology of PE is unclear. Patients …

Human leukocyte antigens in pregnancy and preeclampsia

O Aisagbonhi, GP Morris - Frontiers in Genetics, 2022 - frontiersin.org
Preeclampsia is a pregnancy-induced hypertensive disorder, the pathophysiology of which
includes underlying maternal cardiovascular disease, deficient spiral artery remodeling …

Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia

F Luo, F Liu, Y Guo, W Xu, Y Li, J Yi, T Fournier… - Frontiers in …, 2023 - frontiersin.org
Background Preeclampsia is a pregnancy-specific disorder that always causes maternal
and fetal serious adverse outcome. Disturbances in maternal immune tolerance to embryo at …

[HTML][HTML] Unveiling the hidden players: the crucial role of transposable elements in the placenta and their potential contribution to pre-eclampsia

LM Keighley, CF Lynch-Sutherland, SN Almomani… - Placenta, 2023 - Elsevier
The human placenta is a vital connection between maternal and fetal tissues, allowing for
the exchange of molecules and modulation of immune interactions during pregnancy …

Biological characteristics of HLA-G and its role in solid organ transplantation

S Liu, NA Bos, EAM Verschuuren… - Frontiers in …, 2022 - frontiersin.org
Organ transplantation is a lifesaving option for patients with advanced diseases. Rejection is
regarded as one of the most severe risk factors post-transplantation. A molecule that …

Interleukin-17 promotes proliferation, migration, and invasion of trophoblasts via regulating PPAR-γ/RXR-α/Wnt signaling

Z Zhang, Y Yang, X Lv, H Liu - Bioengineered, 2022 - Taylor & Francis
To investigate the effect of Interleukin 17 (IL-17) on the invasive capacity of trophoblast cells
and the underlying mechanism, we collected placental tissues samples from pregnant …

The enzyme 15-hydroxyprostaglandin dehydrogenase inhibits a shift to the mesenchymal pattern of trophoblasts and decidual stromal cells accompanied by …

H Pang, D Lei, T Chen, Y Liu, C Fan - International Journal of Molecular …, 2023 - mdpi.com
Preeclampsia (PE) is a pregnancy complication beginning after 20 weeks of pregnancy that
involves high blood pressure (systolic> 140 mmHg or diastolic> 90 mmHg), with or without …

[HTML][HTML] Pregnancy induced TMA in severe preeclampsia results from complement-mediated thromboinflammation

AI Lokki, J Heikkinen-Eloranta - Human Immunology, 2021 - Elsevier
Preeclampsia is a multifactorial vascular disease unique to human pregnancy. While genetic
and antiangiogenic factors are important contributors to preeclampsia susceptibility, recent …