Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

It is well established that contracting muscles produce both reactive oxygen and nitrogen
species. Although the sources of oxidant production during exercise continue to be debated …

The observation that muscular exercise is associated with oxidative stress in humans was
first reported over 30years ago. Since this initial report, numerous studies have confirmed …

The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on
intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously …

Ageing is a complex process that in muscle in usually associated with a decrease in mass,
strength, and velocity of contraction. One of the most striking effects of ageing on muscle is …

Abstract Ryanodine receptors (RyRs)/Ca2+ release channels, on the endoplasmic and
sarcoplasmic reticulum of most cell types, are required for intracellular Ca2+ release …

▪ Abstract A surprising variety of ion channels found in a wide range of species from Homo to
Paramecium use calmodulin (CaM) as their constitutive or dissociable Ca2+-sensing …

Ion channels have been studied extensively in ambient O 2 tension (pO 2), whereas tissue
pO 2 is much lower. The skeletal muscle calcium release channel/ryanodine receptor …