In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in
response to alterations in the environment owing to mechanical injury and inflammation …

Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive
impairment. FXS patient exhibit a high comorbidity rate with autism spectrum disorders …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

Hereditary Vitamin D Resistant Rickets (HVDRR) is a rare disease caused by mutations in
the vitamin D receptor (VDR). The consequence of defective VDR is the inability to absorb …

Coordination of neural crest cell (NCC) induction and delamination is orchestrated by
several transcription factors. Among these, Sry-related HMG box-9 (Sox9) and Snail2 have …

Celebrating more than twenty years as the single best source in the field, this Fifth Edition
has now expanded into two cornerstone volumes with 53 fully inclusive chapters and 73 …

Autologous chondrocyte implantation (ACI) has emerged as a new approach to cartilage
repair through the use of harvested chondrocytes. But the expansion of the chondrocytes …

Following induction and activation of the early growth response (Egr)-1 transcription factor in
human chondrocytes, interleukin-1β (IL-1β) suppresses the expression of the type II …

AIMS: Multipotent mesenchymal stromal cells raise great interest for regenerative medicine
studies. Some MSC subpopulations have the potential to undergo neural differentiation …

Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to form the
mechanically responsive matrices of joint tissues, including the menisci of the knee joint …