The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Background Nucleotide metabolism is a critical pathway that generates purine and
pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics …

Efficacy of chemotherapy in the treatment of distinct malignancies is often hampered by drug
resistance arising in the tumor. Understanding the molecular basis of drug resistance and …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Simple Summary Chemotherapy resistance is a common occurrence during cancer
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …

Chemotherapy continues to be a major treatment strategy for various human malignancies.
However, the frequent emergence of chemoresistance compromises chemotherapy efficacy …

Aims Nucleotide de novo synthesis is essential to cell growth and survival, and its
dysregulation leads to cancers and drug resistance. However, how this pathway is …

In this study, the hexapeptide Phe-Ile-Met-Gly-Pro-Tyr (FIMGPY), which has a molecular
weight of 726.9 Da, was separated from skate (Raja porosa) cartilage protein hydrolysate …

Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in
anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors …

Pancreatic enzymes assist metabolic digestion, and hormones like insulin and glucagon
play a critical role in maintaining our blood sugar levels. A malignant pancreas is incapable …