In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …

Abstract Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released from intestinal L-
cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin …

Background Type 1 diabetes is a chronic autoimmune disease that leads to destruction of
insulin-producing beta cells and dependence on exogenous insulin for survival. Some …

The induction of tolerance is a major goal of immunotherapy. Investigations over the last 20
years have shown that anti-CD3 monoclonal antibodies (mAbs) effectively treat autoimmune …

OBJECTIVE The aim of this study was to elucidate whether age plays a role in the
expansion or regeneration of β-cell mass. RESEARCH DESIGN AND METHODS We …

The precise roles of B cells in promoting the pathogenesis of type 1 diabetes remain
undefined. Here, we demonstrate that B cell depletion in mice can prevent or delay diabetes …

For more than 35 years, the NOD mouse has been the primary animal model for studying
autoimmune diabetes. During this time, striking similarities to the human disease have been …

Aims/hypothesis The aim of the study was to examine the 48 month outcome of treating
recent-onset type 1 diabetic patients for 6 days with humanised CD3-antibody, ChAglyCD3 …

Chronic immunological processes that underlie persistent viral infections and autoimmune
disorders such as multiple sclerosis can be relapsing–remitting in nature. The progressive …

Type 1 diabetes (T1D) is an autoimmune disease mediated by a combination of genetic and
environmental triggers resulting in lymphocytic infiltration of pancreatic islets, destruction of …