Noncoding RNA therapeutics—challenges and potential solutions
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
MicroRNA-small molecule association identification: from experimental results to computational models
Small molecule is a kind of low molecular weight organic compound with variety of
biological functions. Studies have indicated that small molecules can inhibit a specific …
biological functions. Studies have indicated that small molecules can inhibit a specific …
Retracted: LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR‐20a‐5p/HMGA2 axis in breast cancer
W Zhao, D Geng, S Li, Z Chen, M Sun - Cancer medicine, 2018 - Wiley Online Library
To study the regulatory effect of lnc RNA HOTAIR/miR‐20a‐5p/HMGA 2 axis on breast
cancer (BC) cell growth, cell mobility, invasiveness, and apoptosis. The microarray data of …
cancer (BC) cell growth, cell mobility, invasiveness, and apoptosis. The microarray data of …
VDA-RWLRLS: An anti-SARS-CoV-2 drug prioritizing framework combining an unbalanced bi-random walk and Laplacian regularized least squares
L Shen, F Liu, L Huang, G Liu, L Zhou… - Computers in biology and …, 2022 - Elsevier
Background A new coronavirus disease named COVID-19, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), is rapidly spreading worldwide …
respiratory syndrome coronavirus-2 (SARS-CoV-2), is rapidly spreading worldwide …
DAESTB: inferring associations of small molecule–miRNA via a scalable tree boosting model based on deep autoencoder
MicroRNAs (miRNAs) are closely related to a variety of human diseases, not only regulating
gene expression, but also having an important role in human life activities and being viable …
gene expression, but also having an important role in human life activities and being viable …
Adaptive boosting-based computational model for predicting potential miRNA-disease associations
Motivation Recent studies have shown that microRNAs (miRNAs) play a critical part in
several biological processes and dysregulation of miRNAs is related with numerous …
several biological processes and dysregulation of miRNAs is related with numerous …
Drug repurposing for cancer therapy
Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …
health. Despite significant advances in surgical, radiotherapeutic and immunological …
Predicting potential small molecule–miRNA associations based on bounded nuclear norm regularization
Mounting evidence has demonstrated the significance of taking microRNAs (miRNAs) as the
target of small molecule (SM) drugs for disease treatment. Given the fact that exploring new …
target of small molecule (SM) drugs for disease treatment. Given the fact that exploring new …
In silico polypharmacology of natural products
Natural products with polypharmacological profiles have demonstrated promise as novel
therapeutics for various complex diseases, including cancer. Currently, many gaps exist in …
therapeutics for various complex diseases, including cancer. Currently, many gaps exist in …
Systems biology based drug repositioning for development of cancer therapy
Drug repositioning is a powerful method that can assists the conventional drug discovery
process by using existing drugs for treatment of a disease rather than its original indication …
process by using existing drugs for treatment of a disease rather than its original indication …