Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

This article addresses the clinical presentation, diagnosis, pathophysiology and
management of narcolepsy type 1 and 2, with a focus on recent findings. A low level of …

Objectives To prospectively evaluate the joint association of duration of rotating night shift
work and lifestyle factors with risk of type 2 diabetes risk, and to quantitatively decompose …

Summary Narcolepsy type 1 (NT1) is a lifelong disorder of sleep-wake dysregulation defined
by clinical symptoms, neurophysiological findings, and low hypocretin levels. Besides a role …

Narcolepsy type 1 and narcolepsy type 2 are central disorders of hypersomnolence.
Narcolepsy type 1 is characterized by excessive daytime sleepiness and cataplexy and is …

After a detailed description of orexins and their roles in sleep and other medical disorders,
we discuss here the current clinical evidence on the effects of dual (DORAs) or selective …

Objectives To assess the frequency and determinants of depressive symptoms and suicidal
thoughts in adults with narcolepsy type 1 (NT1) and controls, as well as the changes after …

Idiopathic hypersomnia (IH) includes a clinical phenotype resembling narcolepsy (with
repeated, short restorative naps), and a phenotype with an excess of sleep, sleep …

Aims To examine the association between a life‐time history of insomnia and hypersomnia
compared with no sleep disturbance and substance use patterns and amounts before and …

Narcolepsy and psychiatric disorders have a significant but unrecognized relationship,
which is an area of evolving interest, but unfortunately, the association is poorly understood …