Microbial dysbiosis in the gut drives systemic autoimmune diseases

WK Mousa, F Chehadeh, S Husband - Frontiers in immunology, 2022 - frontiersin.org
Trillions of microbes survive and thrive inside the human body. These tiny creatures are
crucial to the development and maturation of our immune system and to maintain gut …

Immunopathogenic mechanisms of systemic autoimmune disease

M Wahren-Herlenius, T Dörner - The Lancet, 2013 - thelancet.com
Systemic lupus erythematosus, Sjögren's syndrome, and dermatomyositis are systemic
autoimmune diseases that develop after environmental triggering of genetically susceptible …

Control of lupus nephritis by changes of gut microbiota

Q Mu, H Zhang, X Liao, K Lin, H Liu, MR Edwards… - Microbiome, 2017 - Springer
Background Systemic lupus erythematosus, characterized by persistent inflammation, is a
complex autoimmune disorder with no known cure. Immunosuppressants used in treatment …

Curcumin: A natural modulator of immune cells in systemic lupus erythematosus

AA Momtazi-Borojeni, SM Haftcheshmeh… - Autoimmunity …, 2018 - Elsevier
Curcumin is a polyphenol natural product isolated from turmeric, interacting with different
cellular and molecular targets and, consequently, showing a wide range of pharmacological …

Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients

P López, B de Paz, J Rodríguez-Carrio, A Hevia… - Scientific reports, 2016 - nature.com
Intestinal dysbiosis, characterized by a reduced Firmicutes/Bacteroidetes ratio, has been
reported in systemic lupus erythematosus (SLE) patients. In this study, in vitro cultures …

Th17 cells in immunity and autoimmunity

SK Bedoya, B Lam, K Lau… - Journal of Immunology …, 2013 - Wiley Online Library
Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

Regulatory T cells in systemic lupus erythematosus

K Ohl, K Tenbrock - European journal of immunology, 2015 - Wiley Online Library
Systemic lupus erythematosus (SLE), an autoimmune disease, develops when immunologic
self‐tolerance fails. Treg cells are a subset of CD4+ T cells that maintain self‐tolerance by …

Bite of the wolf: innate immune responses propagate autoimmunity in lupus

S Gupta, MJ Kaplan - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The etiopathogenesis of systemic lupus erythematosus (SLE), a clinically heterogeneous
multisystemic syndrome that derives its name from the initial characterization of facial …

Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension

W Tian, X Jiang, R Tamosiuniene, YK Sung… - Science translational …, 2013 - science.org
Pulmonary hypertension (PH) is a serious condition that affects mainly young and middle-
aged women, and its etiology is poorly understood. A prominent pathological feature of PH …

Lupus nephritis biomarkers

S Soliman, C Mohan - Clinical immunology, 2017 - Elsevier
Lupus nephritis (LN), a potentially destructive outcome of SLE, is a real challenge in the
management of SLE because of the difficulty in diagnosing its subclinical onset and …