Simple Summary Through their regulatory effects on gene expression, histone
acetyltransferases have been implicated in the normal physiological activities and genesis …

The biological regulation of transcription factors (TFs) and repressor proteins is an important
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …

Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate
determination and differentiation. We report that a conserved bromo-adjacent homology …

Multiple Myeloma is an incurable plasma cell malignancy with a poor survival rate that is
usually treated with immunomodulatory drugs (iMiDs) and proteosome inhibitors (PIs). The …

Simple Summary The study discusses the potential of targeting transcription factors (TFs) for
cancer therapy and provide a systematic classification of various types of TFs involved in the …

USP7, one of the most abundant ubiquitin-specific proteases (USP), plays multifaceted roles
in many cellular events, including oncogenic pathways. Accumulated studies have …

The chimeric transcription factor E2A-PBX1, containing the N-terminal activation domains of
E2A fused to the C-terminal DNA-binding domain of PBX1, results in 5% of pediatric acute …

How bone marrow niches regulate leukemogenic activities of leukemia-initiating cells (LICs)
is unclear. The present study revealed that the metabolic niche component, ATP, efficiently …

The clinical outcomes and genomic features of E2A‐PBX1 (TCF3‐PBX1)‐positive B‐cell
acute lymphoblastic leukemia (B‐ALL) patients remain unclear. A total of 137 patients …

TFIID, one of the general transcription factor (GTF), regulates transcriptional initiation of
protein-coding genes through direct binding to promoter elements and subsequent …