Alzheimer's disease (AD) is an age-associated neurodegenerative disease; it is the most
common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily …

Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that
leads to cognitive impairment and memory loss. Emerging evidence suggests that …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in aged
populations. Aberrant amyloid-beta accumulation is a common pathological feature in AD …

Failed communication between mitochondria and lysosomes causes dysfunctional
mitochondria, which may induce mitochondria-related neurodegenerative diseases. Here …

Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of
neuroinflammation in the brain, leading to neurodegeneration in Alzheimer's disease (AD) …

The autophagy-lysosomal pathway (ALP) is a major cellular machinery involved in the
clearance of aggregated proteins in Alzheimer disease (AD). However, ALP is dramatically …

Alzheimer's disease (AD) is a disorder of the central nervous system that is typically marked
by progressive cognitive impairment and memory loss. Amyloid β plaque deposition and …

Objective. Our previous results showed that icariin (ICA) could inhibit apoptosis and provide
neuroprotection against hypoxic‐ischemic brain damage (HIBD) in neonatal mice, but the …

As a classic animal model of Alzheimer's disease (AD), the 3× Tg-AD mouse not only
recapitulates most of anatomical hallmarks observed in AD pathology but also displays …

Extracellular clustering of amyloid-β (Aβ) and an impaired autophagy lysosomal pathway
(ALP) are the hallmark features in the early stages of incurable Alzheimer's disease (AD) …