Background Physical inactivity has been identified as a risk factor for multiple disorders and
a strong association exists between chronic kidney disease (CKD) and a sedentary lifestyle …

Background Chronic kidney disease (CKD) and end-stage renal disease (ESKD) are
significant global health challenges associated with progressive kidney dysfunction and …

The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor
23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes …

We investigated the age-related effects of the lipid-lowering drug fenofibrate on renal stress-
associated effectors. Young and old rats were fed standard chow with 0.1% or 0.5 …

Aging leads to a gradual decline in kidney function, making the kidneys increasingly
vulnerable to various diseases. Oxidative stress, together with cellular senescence, has …

One of the main hallmarks of aging is aging-associated inflammation, also known as
inflammaging. In this study, by comparing plasma and kidney proteome profiling of young …

This study aimed to investigate the impact of various vasculopathies alongside left
ventricular hypertrophy (LVH) on cardiovascular risk in the elderly. This prospective cohort …

SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent class III histone
deacetylase, exhibits a high level of expression within renal tissues. It has garnered …

Metabolic syndrome includes several diseases that are associated with metabolic
abnormalities such as obesity, dyslipidemia, hypertension, type 2 diabetes, obesity, cardiac …

The kidney vasculature has a complex arrangement, which runs in both series and parallel
to perfuse the renal tissue and appropriately filter plasma. Recent studies have …