[HTML][HTML] The biological pathways of Alzheimer disease: A review
M Calabrò, C Rinaldi, G Santoro, C Crisafulli - AIMS neuroscience, 2021 - ncbi.nlm.nih.gov
Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …
people, which severely impairs patients' quality of life. In the recent years, the number of …
Age, APOE and sex: triad of risk of Alzheimer's disease
Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy
AA Belaidi, S Masaldan, A Southon, P Kalinowski… - Molecular …, 2024 - nature.com
Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's
disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is …
disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is …
Expert opinion on benefits of long-chain omega-3 fatty acids (DHA and EPA) in aging and clinical nutrition
B Troesch, M Eggersdorfer, A Laviano, Y Rolland… - Nutrients, 2020 - mdpi.com
Life expectancy is increasing and so is the prevalence of age-related non-communicable
diseases (NCDs). Consequently, older people and patients present with multi-morbidities …
diseases (NCDs). Consequently, older people and patients present with multi-morbidities …
Molecular mechanisms and genetics of oxidative stress in Alzheimer's disease
F Cioffi, RHI Adam, K Broersen - Journal of Alzheimer's …, 2019 - content.iospress.com
Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …
[HTML][HTML] Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease
DA Butterfield, MP Mattson - Neurobiology of disease, 2020 - Elsevier
Inheritance of apolipoprotein E4 (APOE4) is a major risk factor for development of
Alzheimer's disease (AD). This lipoprotein, in contrast to apoE2, has arginine residues at …
Alzheimer's disease (AD). This lipoprotein, in contrast to apoE2, has arginine residues at …
[HTML][HTML] Phytochemicals and cognitive health: Are flavonoids doing the trick?
Flavonoids constitute a large group of polyphenolic compounds with numerous effects on
behaviour and cognition. These effects vary from learning and memory enhancement to an …
behaviour and cognition. These effects vary from learning and memory enhancement to an …
Oxidative damage is the earliest event in Alzheimer disease
Recently, we demonstrated a significant increase of an oxidized nucleoside derived from
RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable …
RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable …
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)
DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear.
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
DA Butterfield, J Drake, C Pocernich… - Trends in molecular …, 2001 - cell.com
Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD)
patients. Free-radical oxidative stress, particularly of neuronal lipids, proteins and DNA, is …
patients. Free-radical oxidative stress, particularly of neuronal lipids, proteins and DNA, is …