MicroRNAs (miRNAs) are single-stranded RNAs of 18–25 nucleotides that regulate gene
expression at the post-transcriptional level. They are involved in many physiological and …

Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …

Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases
associated with chronic activation of type I interferon (IFN) responses, including Aicardi …

In many aspects of life, epigenetics, or the altering of phenotype without changes in
sequences, play an essential role in biological function. A vast number of epigenomic …

Advancements in precision oncology over the past decades have led to new therapeutic
interventions, but the efficacy of such treatments is generally limited by an adaptive process …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date
(n= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

The DNA damage response is essential to safeguard genome integrity. Although the
contribution of chromatin in DNA repair has been investigated,, the contribution of …

Unlike copy number variants (CNVs), inversions remain an underexplored genetic variation
class. By integrating multiple genomic technologies, we discover 729 inversions in 41 …

Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …

Increasing the proportion of locally produced plant protein in currently meat-rich diets could
substantially reduce greenhouse gas emissions and loss of biodiversity. However, plant …