Molecular fluorophores for deep-tissue bioimaging

S Wang, B Li, F Zhang - ACS central science, 2020 - ACS Publications
Fluorescence imaging has made tremendous inroads toward understanding the complexity
of biological systems, but in vivo deep-tissue imaging remains a great challenge due to the …

Intravital imaging to study cancer progression and metastasis

D Entenberg, MH Oktay, JS Condeelis - Nature Reviews Cancer, 2023 - nature.com
Navigation through the bulk tumour, entry into the blood vasculature, survival in the
circulation, exit at distant sites and resumption of proliferation are all steps necessary for …

Brief update on endocytosis of nanomedicines

S Patel, J Kim, M Herrera, A Mukherjee… - Advanced drug delivery …, 2019 - Elsevier
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

Aggregation-induced emission: a trailblazing journey to the field of biomedicine

C Zhu, RTK Kwok, JWY Lam… - ACS Applied Bio Materials, 2018 - ACS Publications
The emergence of the aggregation-induced emission (AIE) concept significantly changes
the cognition of the scientific community toward classic photophysical phenomena. More …

Aggregation-induced emission luminogen with near-infrared-II excitation and near-infrared-I emission for ultradeep intravital two-photon microscopy

J Qi, C Sun, D Li, H Zhang, W Yu, A Zebibula… - ACS …, 2018 - ACS Publications
Currently, a serious problem obstructing the large-scale clinical applications of fluorescence
technique is the shallow penetration depth. Two-photon fluorescence microscopic imaging …

Photochemical mechanisms of fluorophores employed in single‐molecule localization microscopy

K Kikuchi, LD Adair, J Lin, EJ New… - Angewandte Chemie, 2023 - Wiley Online Library
Decoding cellular processes requires visualization of the spatial distribution and dynamic
interactions of biomolecules. It is therefore not surprising that innovations in imaging …

Liver organoids: recent developments, limitations and potential

SP Harrison, SF Baumgarten, R Verma, O Lunov… - Frontiers in …, 2021 - frontiersin.org
Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to
investigate development, toxicity, as well as genetic and infectious disease in ways currently …

NIR‐II‐excited intravital two‐photon microscopy distinguishes deep cerebral and tumor vasculatures with an ultrabright NIR‐I AIE luminogen

S Wang, J Liu, CC Goh, LG Ng, B Liu - Advanced materials, 2019 - Wiley Online Library
Intravital fluorescence imaging of vasculature morphology and dynamics in the brain and in
tumors with large penetration depth and high signal‐to‐background ratio (SBR) is highly …

Fluorescence microscopy—an outline of hardware, biological handling, and fluorophore considerations

SM Hickey, B Ung, C Bader, R Brooks, J Lazniewska… - Cells, 2021 - mdpi.com
Fluorescence microscopy has become a critical tool for researchers to understand biological
processes at the cellular level. Micrographs from fixed and live-cell imaging procedures …

THz pulsed imaging in biomedical applications

A D'Arco, M Di Fabrizio, V Dolci, M Petrarca, S Lupi - Condensed Matter, 2020 - mdpi.com
Recent advances in technology have allowed the production and the coherent detection of
sub-ps pulses of terahertz (THz) radiation. Therefore, the potentialities of this technique have …