p16INK4a immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis

I Tsoumpou, M Arbyn, M Kyrgiou, N Wentzensen… - Cancer treatment …, 2009 - Elsevier
BACKGROUND: P16INK4a is a biomarker for transforming HPV infections that could act as
an adjunct to current cytological and histological assessment of cervical smears and …

P16INK4A immunostaining is a strong indicator for high‐risk‐HPV‐associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low‐risk‐HPV …

JJ Mooren, SE Gültekin, JM Straetmans… - … journal of cancer, 2014 - Wiley Online Library
Human papillomavirus (HPV) is a risk factor for the development of benign and malignant
mucosal head and neck lesions. P16INK4A is often used as a surrogate marker for HPV …

The utility of immunohistochemistry for providing genetic information on tumors

JKC Chan, YT Ip, W Cheuk - International Journal of Surgical …, 2013 - journals.sagepub.com
With advances in immunohistochemical technology and growing knowledge of the
molecular genetics of tumors, immunohistochemistry is playing an increasingly important …

Immunochemical analysis of HPV L1 capsid protein and p16 protein in liquid‐based cytology samples from uterine cervical lesions

T Yoshida, T Sano, T Kanuma, N Owada… - … Journal of the …, 2008 - Wiley Online Library
Abstract BACKGROUND HPV L1 capsid protein is expressed together with the production of
infectious viral particles, but its expression and relation to p16 expression, which has been a …

Observation of the cervical microbiome in the progression of cervical intraepithelial neoplasia

H Wang, Y Jiang, Y Liang, L Wei, W Zhang, L Li - BMC cancer, 2022 - Springer
Objective Cervical microbial community in the cervical intraepithelial neoplasia and cervical
cancer patients was analysed to study its composition, diversity and signalling pathways by …

Mucosal alpha‐papillomaviruses are not associated with esophageal squamous cell carcinomas: Lack of mechanistic evidence from S outh A frica, C hina and I ran …

G Halec, M Schmitt, S Egger, CC Abnet… - … journal of cancer, 2016 - Wiley Online Library
Epidemiological and mechanistic evidence on the causative role of human papillomaviruses
(HPV) in esophageal squamous cell carcinoma (ESCC) is unclear. We retrieved alcohol …

[HTML][HTML] Deregulation of p27 and cyclin D1/D3 control over mitosis is associated with unfavorable prognosis in non-small cell lung cancer, as determined in 405 …

W Sterlacci, M Fiegl, W Hilbe, H Jamnig… - Journal of thoracic …, 2010 - Elsevier
Introduction A large group of interacting molecular factors, involved in
epithelialmesenchymal transition, epidermal growth factor receptor (EGFR) signaling, and …

Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions—a Taiwanese Gynecologic Oncology …

H Lin, TC Chen, TC Chang, YM Cheng, CH Chen… - Gynecologic …, 2014 - Elsevier
Objective Our previous work revealed that host genes ZNF582, PTPRR, PAX1, and SOX1
are highly methylated in cervical intraepithelial neoplasias grade 3 or worse (CIN3+). In this …

Post‐cervical conization outcomes in patients with high‐grade intraepithelial lesions

RB Simões, AB Campaner - Apmis, 2013 - Wiley Online Library
To investigate the rates of residual, recurrent and invasive disease after cervical conization
in patients diagnosed with cervical intraepithelial neoplasia (CIN) grades 2/3. A …

Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes

MA Merkley, E Hildebrandt, RH Podolsky, H Arnouk… - Proteome science, 2009 - Springer
Background Infection with high-risk type human papilloma viruses (HPVs) is associated with
cervical carcinomas and with a subset of head and neck squamous cell carcinomas. Viral E6 …