Methionine metabolism in health and cancer: a nexus of diet and precision medicine
Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
Metabolic hallmarks of tumor and immune cells in the tumor microenvironment
K Renner, K Singer, GE Koehl, EK Geissler… - Frontiers in …, 2017 - frontiersin.org
Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor
cells and the number and activity of tumor-infiltrating T cells represent a good marker for …
cells and the number and activity of tumor-infiltrating T cells represent a good marker for …
A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension
Methionine is an essential amino acid with many key roles in mammalian metabolism such
as protein synthesis, methylation of DNA and polyamine synthesis. Restriction of methionine …
as protein synthesis, methylation of DNA and polyamine synthesis. Restriction of methionine …
Characterization of a Germ-Line Deletion, Including the Entire INK4/ARF Locus, in a Melanoma-Neural System Tumor Family: Identification of ANRIL, an Antisense Noncoding …
E Pasmant, I Laurendeau, D Héron, M Vidaud… - Cancer research, 2007 - AACR
We have previously detected a large germ-line deletion, which included the entire
p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the largest melanoma-neural system …
p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the largest melanoma-neural system …
Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis: comparison with 9p21 FISH and BAP1 immunohistochemistry
T Hida, M Hamasaki, S Matsumoto, A Sato, T Tsujimura… - Lung Cancer, 2017 - Elsevier
Objectives Differentiating malignant pleural mesothelioma (MPM) from reactive mesothelial
hyperplasia (RMH) is still challenging. Detection of homozygous deletion (HD) of 9p21 …
hyperplasia (RMH) is still challenging. Detection of homozygous deletion (HD) of 9p21 …
MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural …
DB Chapel, JJ Schulte, K Berg, A Churg, S Dacic… - Modern …, 2020 - nature.com
Ancillary studies facilitate accurate diagnosis of morphologically challenging mesothelial
proliferations. The current diagnostic algorithm proceeds from BAP1 immunohistochemistry …
proliferations. The current diagnostic algorithm proceeds from BAP1 immunohistochemistry …
Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis
AS Schaefer, GM Richter, B Groessner-Schreiber… - PLoS …, 2009 - journals.plos.org
Recent studies indicate a mutual epidemiological relationship between coronary heart
disease (CHD) and periodontitis. Both diseases are associated with similar risk factors and …
disease (CHD) and periodontitis. Both diseases are associated with similar risk factors and …
The emerging role of PRMT6 in cancer
Z Chen, J Gan, Z Wei, M Zhang, Y Du, C Xu… - Frontiers in …, 2022 - frontiersin.org
Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that is involved in epigenetic
regulation of gene expression through methylating histone or non-histone proteins, and …
regulation of gene expression through methylating histone or non-histone proteins, and …
Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
A high melanocytic nevi count is the strongest known risk factor for cutaneous melanoma.
We conducted a genome-wide association study for nevus count using 297,108 SNPs in …
We conducted a genome-wide association study for nevus count using 297,108 SNPs in …
Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease
F Aguilo, S Di Cecilia, MJ Walsh - Long Non-coding RNAs in human …, 2016 - Springer
The long non-coding RNA CDKN2B-AS1, commonly referred to as the A ntisense N on-
coding R NA in the I NK4 L ocus (ANRIL), is a 3.8-kb-long RNA transcribed from the short …
coding R NA in the I NK4 L ocus (ANRIL), is a 3.8-kb-long RNA transcribed from the short …