The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Circadian Mechanisms in Medicine Molecular insights into diurnal variations in human
physiology and behavior are extending our understanding of a wide range of disease …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

The circadian system, that is ubiquitous across species, generates∼ 24 h rhythms in
virtually all biological processes, and allows them to anticipate and adapt to the 24 h …

Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

The discovery that half of the mammalian protein-coding genome is regulated by the
circadian clock has clear implications for medicine. Recent studies demonstrated that the …