Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …

Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

Background & Aims Chronic hepatitis C virus infection activates an intrahepatic immune
response, leading to increased expression of interferon (IFN)-stimulated genes and …

Despite development of new antiviral drugs, viral infections are still a major health problem.
The most potent antiviral defense mechanism is the innate production of type I interferon …

Abstract The role of Natural Killer cells in host defense against infections as well as in
tumour surveillance has been widely appreciated for a number of years. Upon recognition of …

Natural killer cells (NK s) are involved in every stage of hepatitis C viral (HCV) infection, from
protection against HCV acquisition and resolution in the acute phase to treatment‐induced …

Natural killer (NK) cells are traditionally regarded as first-line effectors of the innate immune
response, but they also have a distinct role in chronic infection. Here, we review the role of …

Patients infected with the hepatitis C virus (HCV) are characterized by a high incidence of
chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular …

Objective Chronic HCV infection is characterised by innate immune activation with
increased interferon-stimulated genes (ISG) expression and by an altered phenotype of …

Objective Sialic-acid-binding immunoglobulin-like lectin-7 (Siglec-7) is a natural killer (NK)
cell inhibitory receptor associated with NK phenotypic and functional abnormalities in HIV-1 …