Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …

The emergency use authorization of two mRNA vaccines in less than a year from the
emergence of SARS-CoV-2 represents a landmark in vaccinology,. Yet, how mRNA …

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
effective in preventing hospitalization from severe COVID-19. However, multiple reports of …

Early responses to vaccination are important for shaping both humoral and cellular
protective immunity. Dissecting innate vaccine signatures may predict immunogenicity to …

Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …

Epidemiological data suggest that early life exposures are key determinants of immune-
mediated disease later in life. Young children are also particularly susceptible to infections …

Females typically develop higher antibody responses and experience more adverse
reactions following vaccination than males. These differences are observed in response to …

Cancer immunotherapy attempts to harness the power and specificity of the immune system
to treat tumours. The molecular identification of human cancer-specific antigens has allowed …

Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …