Translating neurobehavioral toxicity across species from zebrafish to rats to humans: implications for risk assessment
CV Vorhees, MT Williams, AB Hawkey… - Frontiers in …, 2021 - frontiersin.org
There is a spectrum of approaches to neurotoxicological science from high-throughput in
vitro cell-based assays, through a variety of experimental animal models to human …
vitro cell-based assays, through a variety of experimental animal models to human …
Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform
Developmental toxicity testing urgently requires the implementation of human-relevant new
approach methodologies (NAMs) that better recapitulate the peculiar nature of human …
approach methodologies (NAMs) that better recapitulate the peculiar nature of human …
G× E interactions as a basis for toxicological uncertainty
To transfer toxicological findings from model systems, eg animals, to humans, standardized
safety factors are applied to account for intra-species and inter-species variabilities. An …
safety factors are applied to account for intra-species and inter-species variabilities. An …
Prediction of the neurotoxic potential of chemicals based on modelling of molecular initiating events upstream of the adverse outcome pathways of (developmental) …
D Gadaleta, N Spînu, A Roncaglioni… - International Journal of …, 2022 - mdpi.com
Developmental and adult/ageing neurotoxicity is an area needing alternative methods for
chemical risk assessment. The formulation of a strategy to screen large numbers of …
chemical risk assessment. The formulation of a strategy to screen large numbers of …
Zebrafish and nematodes as whole organism models to measure developmental neurotoxicity
S Hughes, EVS Hessel - Critical Reviews in Toxicology, 2024 - Taylor & Francis
Despite the growing epidemiological evidence of an association between toxin exposure
and developmental neurotoxicity (DNT), systematic testing of DNT is not mandatory in …
and developmental neurotoxicity (DNT), systematic testing of DNT is not mandatory in …
Characterization of developmental neurobehavioral toxicity in a zebrafish MPTP-induced model: A novel mechanism involving anemia
H Dong, L Mao, C Bai, K Ye, H Wu, Y Lei… - ACS Chemical …, 2022 - ACS Publications
Zebrafish represent an economical alternative to rodents for developmental neurotoxicity
(DNT) testing. Mechanistic understanding is the key to successfully translating zebrafish …
(DNT) testing. Mechanistic understanding is the key to successfully translating zebrafish …
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
MM Serafini, S Sepehri, M Midali, M Stinckens… - Archives of …, 2024 - Springer
Adult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to
understand the adverse effects and underlying mechanisms of toxicants on the human …
understand the adverse effects and underlying mechanisms of toxicants on the human …
Current activities between the DevTox Berlin workshops and the Japanese Teratology Society Terminology Committee in harmonizing the terminology for classifying …
M Kuwagata, A Sato, Y Izumi, K Chihara… - Congenital …, 2022 - Wiley Online Library
In recent years, the Japanese Teratology Society has worked with the DevTox Berlin
Workshops project to provide internationally consistent terminology for teratogenic effects …
Workshops project to provide internationally consistent terminology for teratogenic effects …
[PDF][PDF] Challenges and solution approaches for an improved assessment of reproductive toxicity–species differences and in silico predictions
A Weyrich - 2022 - kluedo.ub.rptu.de
Within toxicology, reproductive toxicology is a highly relevant and socially particularly
sensitive field. It encompasses all toxicological processes within the reproductive cycle and …
sensitive field. It encompasses all toxicological processes within the reproductive cycle and …