7-Azaindole N-Oxide (7-AINO) Mediated Cu-Catalyzed N-Arylation: Mechanistic Investigation into the Role of Fluoride Ions

K Mondal, N Mukhopadhyay, S Patra, T Roy… - ACS Catalysis, 2023 - ACS Publications
A Cu (II) fluoride-catalyzed N-arylation of 7-azaindole N-oxides (7-AINO) has been
developed using boronic acid under base-free conditions. During the process, a …

Recent advances in transition-metal-free late-stage CH and NH arylation of heteroarenes using diaryliodonium salts

T Besson, C Fruit - Pharmaceuticals, 2021 - mdpi.com
Transition-metal-free direct arylation of CH or NH bonds is one of the key emerging
methodologies that is currently attracting tremendous attention. Diaryliodonium salts serve …

Recent Progress Concerning the N-Arylation of Indoles

P Oeser, J Koudelka, A Petrenko, T Tobrman - Molecules, 2021 - mdpi.com
This review summarizes the current state-of-the-art procedures in terms of the preparation of
N-arylindoles. After a short introduction, the transition-metal-free procedures available for …

Entering chemical space with theoretical underpinning of the mechanistic pathways in the Chan–Lam amination

S Bose, S Dutta, D Koley - ACS Catalysis, 2022 - ACS Publications
Recent years have witnessed a growing interest in the development of efficient copper-
based catalytic systems following the Chan–Lam (CL) reaction protocol for the C–N bond …

Catalysis of surface dispersed Cu 2+ species on t-ZrO 2: square-planar Cu catalyzed cross-coupling of arylboronic acid and imidazole

M Kondo, T Joutsuka, K Fujiwara, T Honma… - Catalysis Science & …, 2023 - pubs.rsc.org
We examined the Chan–Lam cross-coupling of imidazole and arylboronic acids under
additive-free and mild conditions using heterogeneous CuO/MOX catalysts such as metal …

Synthesis of Unsymmetrical Biheteroarenes via Dehydrogenative and Decarboxylative Coupling: a Decade Update

S Majumder, S Ghosh, P Pyne, A Ghosh… - The Chemical …, 2022 - Wiley Online Library
The design and development of robust and efficient methods for installing one heterocycle
with another is endowed as a ubiquitous and powerful synthetic strategy to access complex …

Access to N-Aryl (Iso)quinolones via Aryne-Induced Three-Component Coupling Reaction

Q Yan, Z Zhuang, R Fan, J Wang, T Yao, J Tan - Organic Letters, 2024 - ACS Publications
N-Aryl (iso) quinolones are of increasing interest in material and medicinal chemistry,
although general routes for their provision remain underexplored, especially when …

Ullmann-Type N-, S-, and O-Arylation Using a Well-Defined 7-Azaindole-N-oxide (7-AINO)-Based Copper(II) Catalyst: Scope and Application to Drug Synthesis

V Talukdar, K Mondal, P Halder… - The Journal of Organic …, 2024 - ACS Publications
An air-stable, robust, and well-defined copper (II)-7-azaindole-N-oxide-based catalyst [Cu2II
(7-AINO) 4](abbreviated as Cu (II)-7-AINO) has been demonstrated as an efficient catalyst …

2, 2, 5, 5-Tetramethyloxolane (TMO) as a Solvent for Buchwald–Hartwig Aminations

BR Trowse, FP Byrne, J Sherwood… - ACS Sustainable …, 2021 - ACS Publications
Buchwald–Hartwig amination is one of the most important methods for the synthesis of N-
arylamines and is widely employed for the synthesis of potential pharmaceuticals, natural …

Indolyl-based Copper (I) Complex-Catalyzed Intermolecular Trifluoromethylazolation of Alkenes via Radical Process

Q Yuan, Z Huang, Z Chai, D Hong, S Zhu, S Zhou… - Organic …, 2022 - ACS Publications
Herein, we synthesized and characterized a binuclear copper (I) complex supported by the
indolyl-based ligand. Employing this complex as catalyst, we have developed a three …