In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …

Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate
phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step …

Simple Summary Non-alcoholic fatty liver disease (NAFLD) is an unmet medical need due to
its increasingly high incidence, severe clinical consequences, and the absence of feasible …

The numerous biological roles of NAD+ are organized and coordinated via its
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …

Nicotinamide phosphoribosyltransferase (NAMPT) possesses a vital role in mammalian
cells due to its activity as a rate-limiting enzyme in the biosynthesis of nicotinamide adenine …

Nicotinamide phosphoribosyl transferase (NAMPT) is considered as a promising target for
cancer therapy given its critical engagement in cancer metabolism and inflammation …

Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …

Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female
reproductive tract causing high morbidity as they can significantly affect fertility and quality of …

Nicotinamide phosphoribosyltransferase (NAMPT) is the bottleneck enzyme of the NAD
salvage pathway and thereby is a controller of intracellular NAD concentrations. It has been …