Aptamer-based targeted protein degradation

Y Liu, X Qian, C Ran, L Li, T Fu, D Su, S Xie, W Tan - ACS nano, 2023 - ACS Publications
The selective removal of misfolded, aggregated, or aberrantly overexpressed protein plays
an essential role in maintaining protein-dominated biological processes. In parallel, the …

[HTML][HTML] Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review

A Doustmihan, M Fathi, MA Mazloomi, A Salemi… - Journal of Controlled …, 2023 - Elsevier
There is increasing evidence that malignant tumors are initiated and maintained by a sub-
population of tumor cells that have similar biological properties to normal adult stem cells …

Hierarchical Au nanoarrays functionalized 2D Ti2CTx MXene membranes for the detection of exosomes isolated from human lung carcinoma cells

Q You, L Zhuang, Z Chang, M Ge, Q Mei, L Yang… - Biosensors and …, 2022 - Elsevier
Exosome is considered an important biomarker of liquid biopsy in early cancer screening,
which can reflect the physiological and pathological status of cancer cells. Herein, we …

Aptamer-functionalized liposomes for targeted cancer therapy

SA Moosavian, P Kesharwani, V Singh… - … Nanocarriers for Cancer …, 2023 - Elsevier
Liposomes are among the most well-documented drug delivery systems in anticancer
therapy owing to their passive targeting capacities besides inherent biocompatibility and …

[HTML][HTML] Identification and structural analysis of novel malathion-specific DNA aptameric sensors designed for food testing

US Kadam, KH Trinh, V Kumar, KW Lee, Y Cho… - Biomaterials, 2022 - Elsevier
Malathion is an organophosphate chemical (OPC) and a toxic contaminant that adversely
impacts food quality, human health, biodiversity, and the environment. Due to its small size …

Hybridized quantum dot, silica, and gold nanoparticles for targeted chemo-radiotherapy in colorectal cancer theranostics

A Abrishami, AR Bahrami, S Nekooei… - Communications …, 2024 - nature.com
Multimodal nanoparticles, utilizing quantum dots (QDs), mesoporous silica nanoparticles
(MSNs), and gold nanoparticles (Au NPs), offer substantial potential as a smart and targeted …

A colorimetric aptasensor based on a hemin/EpCAM aptamer DNAzyme for sensitive exosome detection

J Kuang, Z Fu, X Sun, C Lin, S Yang, J Xu, M Zhang… - Analyst, 2022 - pubs.rsc.org
Exosomes are considered as potential biomarkers that can reflect information from their
parent cell-associated cancer microenvironment. Recently, aptasensors have been widely …

Anti-Epcam aptamer (Syl3c)-functionalized liposome for targeted delivery of doxorubicin: In vitro and in vivo antitumor studies in mice bearing C26 colon carcinoma

M Mashreghi, P Zamani, SA Moosavian… - Nanoscale Research …, 2020 - Springer
In this study, we have surface-functionalized PEGylated-nanoliposomal doxorubicin (DOX)
with anti-EpCAM (epithelial cell adhesion molecule) aptamer via post-insertion of anti …

Aptamer-conjugated mesoporous silica nanoparticles for simultaneous imaging and therapy of cancer

S Vandghanooni, J Barar, M Eskandani… - TrAC Trends in Analytical …, 2020 - Elsevier
Mesoporous silica nanoparticles (MSNs) possess wide requirements for successful drug
delivery, due to their superior physicochemical properties such as the well-organized porous …

In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers

DR Bell, JK Weber, W Yin, T Huynh… - Proceedings of the …, 2020 - National Acad Sciences
Nucleic acid aptamers hold great promise for therapeutic applications due to their favorable
intrinsic properties, as well as high-throughput experimental selection techniques. Despite …