Insights into the structure of class B GPCRs
K Hollenstein, C de Graaf, A Bortolato… - Trends in …, 2014 - cell.com
The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in
hormonal homeostasis and are interesting drug targets for the treatment of several metabolic …
hormonal homeostasis and are interesting drug targets for the treatment of several metabolic …
Transmembrane signal transduction by peptide hormones via family BG protein-coupled receptors
Although family BG protein-coupled receptors (GPCRs) contain only 15 members, they play
key roles in transmembrane signal transduction of hormones. Family B GPCRs are drug …
key roles in transmembrane signal transduction of hormones. Family B GPCRs are drug …
Structure of the human glucagon class B G-protein-coupled receptor
Binding of the glucagon peptide to the glucagon receptor (GCGR) triggers the release of
glucose from the liver during fasting; thus GCGR plays an important role in glucose …
glucose from the liver during fasting; thus GCGR plays an important role in glucose …
Parasympathetic innervation regulates tubulogenesis in the developing salivary gland
PI Nedvetsky, E Emmerson, JK Finley, A Ettinger… - Developmental cell, 2014 - cell.com
A fundamental question in development is how cells assemble to form a tubular network
during organ formation. In glandular organs, tubulogenesis is a multistep process requiring …
during organ formation. In glandular organs, tubulogenesis is a multistep process requiring …
Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR
Molecular determinants regulating the activation of class B G-protein-coupled receptors
(GPCRs) by native peptide agonists are largely unknown. We have investigated here the …
(GPCRs) by native peptide agonists are largely unknown. We have investigated here the …
Conformational states of the full-length glucagon receptor
Class BG protein-coupled receptors are composed of an extracellular domain (ECD) and a
seven-transmembrane (7TM) domain, and their signalling is regulated by peptide hormones …
seven-transmembrane (7TM) domain, and their signalling is regulated by peptide hormones …
Understanding VPAC receptor family peptide binding and selectivity
The vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating
polypeptide (PACAP) receptors are key regulators of neurological processes. Despite recent …
polypeptide (PACAP) receptors are key regulators of neurological processes. Despite recent …
Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R)
D Yang, C de Graaf, L Yang, G Song, A Dai… - Journal of Biological …, 2016 - ASBMB
The glucagon-like peptide-1 receptor (GLP-1R) belongs to the secretin-like (class B) family
of G protein-coupled receptors. Members of the class B family are distinguished by their …
of G protein-coupled receptors. Members of the class B family are distinguished by their …
Structure-based multifunctionalization of flexuous elongated viral nanoparticles
C Yuste-Calvo, I González-Gamboa, LF Pacios… - ACS …, 2019 - ACS Publications
Nanoparticle multifunctionalization has become an important goal in many nanoscience-
related areas because it allows different simultaneous applications with the same …
related areas because it allows different simultaneous applications with the same …
Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies
I Langer - Frontiers in endocrinology, 2012 - frontiersin.org
Vasoactive intestinal peptide (VIP) plays diverse and important role in human physiology
and physiopathology and their receptors constitute potential targets for the treatment of …
and physiopathology and their receptors constitute potential targets for the treatment of …