Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides

YP Pang, S Brimijoin, DW Ragsdale… - Current drug …, 2012 - ingentaconnect.com
Insect pests are responsible for human suffering and financial losses worldwide. New and
environmentally safe insecticides are urgently needed to cope with these serious problems …

An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Japanese encephalitis vector mosquito, Culex tritaeniorhynchus

T Nabeshima, A Mori, T Kozaki, Y Iwata, O Hidoh… - Biochemical and …, 2004 - Elsevier
A cDNA sequence encoding a Drosophila Ace-paralogous acetylcholinesterase (AChE)
precursor of 701 amino acid residues was identified as the second AChE gene (Ace2) …

Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point mutations

T Kozaki, T Shono, T Tomita, Y Kono - Insect Biochemistry and Molecular …, 2001 - Elsevier
The cDNA of AChE in the housefly, Musca domestica, was sequenced and individual flies
were genotyped by this gene in an inhibition assay of AChE activity with an …

Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider mite, Tetranychus urticae

Y Anazawa, T Tomita, Y Aiki, T Kozaki… - Insect biochemistry and …, 2003 - Elsevier
Acetylcholinesterase (AChE) from two-spotted spider mites, Tetranychus urticae was
compared between an organophosphate susceptible (TKD) and a resistant (NCN) strain …

[HTML][HTML] Common substitution mutation F348Y of acetylcholinesterase gene contributes to organophosphate and carbamate resistance in Cimex lectularius and C …

O Komagata, S Kasai, K Itokawa, K Minagawa… - Insect Biochemistry and …, 2021 - Elsevier
Bed bug control highly depends on insecticides with a limited number of modes of action,
especially since the global prevalence of pyrethroid resistance. De facto insecticide options …

Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides

YP Pang, SK Singh, Y Gao, TL Lassiter, RK Mishra… - PLoS …, 2009 - journals.plos.org
Aphids, among the most destructive insects to world agriculture, are mainly controlled by
organophosphate insecticides that disable the catalytic serine residue of …

Amino acid substitutions conferring insecticide insensitivity in Ace-paralogous acetylcholinesterase

Y Kono, T Tomita - Pesticide biochemistry and physiology, 2006 - Elsevier
Since insecticide insensitivity of acetylcholinesterase (AChE) was, found about 40 years
ago, a cause of the resistance to organophosphates in the spider mite, more than 30 insect …

Absence of protein polymorphism attributable to insecticide-insensitivity of acetylcholinesterase in the green rice leafhopper, Nephotettix cincticeps

T Tomita, O Hidoh, Y Kono - Insect Biochemistry and Molecular Biology, 2000 - Elsevier
The cDNA sequence of acetylcholinesterase (AChE) from the green rice leafhopper,
Nephotettix cincticeps, was amplified, based on conserved peptide sequences of AChEs. A …

Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases

YP Pang, F Ekström, GA Polsinelli, Y Gao, S Rana… - PLoS …, 2009 - journals.plos.org
New insecticides are urgently needed because resistance to current insecticides allows
resurgence of disease-transmitting mosquitoes while concerns for human toxicity from …

Expression of Ace-paralogous acetylcholinesterase of Culex tritaeniorhynchus with an amino acid substitution conferring insecticide insensitivity in baculovirus-insect …

SH Oh, T Kozaki, H Mizuno, T Tomita, Y Kono - Pesticide biochemistry and …, 2006 - Elsevier
In Ace paralogous acetylcholinesterase (AP-AChE) of Culex tritaeniorhynchus, an amino
acid substitution, Phe455Trp, is accompanied by the insecticide insensitivity. To confirm the …