CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics
across a wide range of organisms, including the Plasmodium parasites that cause malaria …

Apicomplexan parasites Toxoplasma gondii and Plasmodium spp. use latent stages to
persist in the host, facilitate transmission, and thwart treatment of infected patients …

The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …

Chondroitin sulfate (CS) is a sulfated polysaccharide that plays essential physiological roles.
Here, we report an enzyme‐based method for the synthesis of a library of 15 different CS …

Malaria parasites avoid immune clearance through their ability to systematically alter
antigens exposed on the surface of infected red blood cells. This is accomplished by tightly …

Translational control regulates the levels of protein synthesized from its transcript and is key
for the rapid adjustment of gene expression in response to environmental stimuli. The …

Thermorubin (THB) is a long-known broad-spectrum ribosome-targeting antibiotic, but the
molecular mechanism of its action was unclear. Here, our precise fast-kinetics assays in a …

How aminoglycoside antibiotics limit bacterial growth and viability is not clearly understood.
Here we employ fast kinetics to reveal the molecular mechanism of action of a clinically …

Gametocytes and sporozoites must both overcome similar obstacles. After fully maturing,
they must lie in wait and be prepared for a fleeting moment when a mosquito takes a blood …

The most severe form of malaria, caused by infection with Plasmodium falciparum parasites,
continues to be an important cause of human suffering and poverty. The P. falciparum …