This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …

Antibiotics revolutionized medicine and remain its cornerstone. Despite their global
importance and the continuous threat of resistant pathogens, few antibiotics have been …

Antimicrobial resistance is a global health crisis and few novel antimicrobials have been
discovered in recent decades. Natural products, particularly from Streptomyces, are the …

Advances in genomics and metabolomics have made clear in recent years that microbial
biosynthetic capacities on Earth far exceed previous expectations. This is attributable, in …

Microbial symbionts are often a source of chemical novelty and can contribute to host
defense against antagonists. However, the ecological relevance of chemical mediators …

The human microbiome encodes a second genome that dwarfs the genetic capacity of the
host. Microbiota-derived small molecules can directly target human cells and their receptors …

Shotgun metagenomics is a powerful, high-resolution technique enabling the study of
microbial communities in situ. However, species-level resolution is only achieved after a …

Trans-acyltransferase polyketide synthases (trans-AT PKSs) are bacterial multimodular
enzymes that biosynthesize diverse pharmaceutically and ecologically important …

Symbiotic mutualisms of bacteria and animals are ubiquitous in nature, running a continuum
from facultative to obligate from the perspectives of both partners. The loss of functions …

Antibiotic resistance is a global threat to public health, further accelerated by the misuse of
antibiotics in humans and animals. Our recent studies have shown that gut bacteria of …