Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in
cancer remain unclear. The tumour suppressor BRCA1-associated protein 1 (BAP1) …

Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

Uveal melanoma is an aggressive malignancy that originates from melanocytes in the eye.
Even if the primary tumor has been successfully treated with radiation or surgery, up to half …

Genetic screens are critical for the systematic identification of genes underlying cellular
phenotypes. Pooling gene perturbations greatly improves scalability but is not compatible …

The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-
genome and exome sequencing followed by innovative tumorgraft analyses (to accurately …

BAP1 is a deubiquitylase that is found associated with multiprotein complexes that regulate
key cellular pathways, including the cell cycle, cellular differentiation, cell death …

Metastasis is a defining feature of malignant tumors and is the most common cause of
cancer-related death, yet the genetics of metastasis are poorly understood. We used exome …