Nanoparticle-mediated targeted drug delivery to remodel tumor microenvironment for cancer therapy

L Tang, Y Mei, Y Shen, S He, Q Xiao, Y Yin… - International Journal …, 2021 - Taylor & Francis
Advanced research has revealed the crucial role of tumor microenvironment (TME) in
tumorigenesis. TME consists of a complicated network with a variety of cell types including …

[HTML][HTML] Gold nanomaterials for oral cancer diagnosis and therapy: advances, challenges, and prospects

Q Zhang, D Hou, X Wen, M Xin, Z Li, L Wu, JL Pathak - Materials Today Bio, 2022 - Elsevier
Early diagnosis and treatment of oral cancer are vital for patient survival. Since the oral
cavity accommodates the second largest and most diverse microbiome community after the …

Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells

B Das, SR Dash, H Patel, S Sinha, S Bhal, S Paul… - Phytomedicine, 2023 - Elsevier
Background Breast cancer stem cells (BCSCs) have a critical role in progression of breast
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …

Nano-drug delivery systems in oral cancer therapy: recent developments and prospective

Y Zhang, Y Wu, H Du, Z Li, X Bai, Y Wu, H Li, M Zhou… - Pharmaceutics, 2023 - mdpi.com
Oral cancer (OC), characterized by malignant tumors in the mouth, is one of the most
prevalent malignancies worldwide. Chemotherapy is a commonly used treatment for OC; …

Near-infrared enhances antiangiogenic potentiality of quinacrine-gold hybrid nanoparticles in breast cancer stem cells via deregulation of HSP-70/TGF-β

SR Dash, B Das, C Das, S Sinha, S Paul… - …, 2023 - Taylor & Francis
Aim: This study aimed to explore the antiangiogenic mechanism of quinacrine-gold hybrid
nanoparticle (QAuNP) and near-infrared (NIR) radiation in patient-derived primary breast …

Talazoparib enhances the quinacrine-mediated apoptosis in patient-derived oral mucosa CSCs by inhibiting BER pathway through the modulation of GCN5 and P300

C Das, SR Dash, S Sinha, S Paul, B Das, S Bhal… - Medical Oncology, 2023 - Springer
The presence of cancer stem cells (CSCs) in the tumor microenvironment (TME) is majorly
responsible for the development and recurrence of cancer. Earlier reports suggested that …

Cancer stem cell (CSC) inhibitors in oncology—a promise for a better therapeutic outcome: state of the art and future perspectives

PS Kharkar - Journal of Medicinal Chemistry, 2020 - ACS Publications
Cancer stem cells (CSCs), a subpopulation of cancer cells endowed with self-renewal,
tumorigenicity, pluripotency, chemoresistance, differentiation, invasive ability, and plasticity …

NIR irradiation enhances the apoptotic potentiality of quinacrine-gold hybrid nanoparticles by modulation of HSP-70 in oral cancer stem cells

SR Dash, S Chatterjee, S Sinha, B Das, S Paul… - … , Biology and Medicine, 2022 - Elsevier
Cancer stem cells (CSCs) are the tumor cell subpopulations that can self-renew,
differentiate, initiate and maintain tumor growth. CSCs are frequently drug-resistant …

Near infrared-responsive quinacrine–gold hybrid nanoparticles deregulate HSP-70/P300-mediated H3K14 acetylation in ER/PR+ breast cancer stem cells

SR Dash, C Das, B Das, AB Jena, S Paul, S Sinha… - …, 2024 - Taylor & Francis
Aim: This study aimed to determine if quinacrine–gold hybrid nanoparticles (QAuNPs)+ near-
infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen …

Repurposing of anti-malarial drug quinacrine for cancer treatment: a review

M Kumar, A Sarkar - Scientia Pharmaceutica, 2022 - mdpi.com
Quinacrine (QC), a synthetic drug belonging to the 9-aminoacridine family, has been used
extensively to treat malaria and multiple ailments over the past several decades. Following …