Update on the effects of microgravity on the musculoskeletal system

OJ Juhl IV, EG Buettmann, MA Friedman… - npj …, 2021 - nature.com
With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

The impact of microgravity on bone in humans

D Grimm, J Grosse, M Wehland, V Mann, JE Reseland… - Bone, 2016 - Elsevier
Experiencing real weightlessness in space is a dream for many of us who are interested in
space research. Although space traveling fascinates us, it can cause both short-term and …

The cardiovascular system in space: focus on in vivo and in vitro studies

R Baran, S Marchal, S Garcia Campos, E Rehnberg… - Biomedicines, 2021 - mdpi.com
On Earth, humans are subjected to a gravitational force that has been an important
determinant in human evolution and function. During spaceflight, astronauts are subjected to …

Modeling host-pathogen interactions in the context of the microenvironment: three-dimensional cell culture comes of age

J Barrila, A Crabbé, J Yang, K Franco… - Infection and …, 2018 - Am Soc Microbiol
Tissues and organs provide the structural and biochemical landscapes upon which
microbial pathogens and commensals function to regulate health and disease. While flat two …

Muscle-bone interactions: From experimental models to the clinic? A critical update

MR Laurent, V Dubois, F Claessens… - Molecular and cellular …, 2016 - Elsevier
Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

D Grimm, M Wehland, TJ Corydon… - Stem cells …, 2020 - academic.oup.com
A spaceflight has enormous influence on the health of space voyagers due to the combined
effects of microgravity and cosmic radiation. Known effects of microgravity (μ g) on cells are …

Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation

Z Chen, Q Luo, C Lin, D Kuang, G Song - Scientific reports, 2016 - nature.com
Microgravity induces observed bone loss in space flight and reduced osteogenesis of bone
mesenchymal stem cells (BMSCs) partly contributes to this phenomenon. Abnormal …

Tissue engineering under microgravity conditions–use of stem cells and specialized cells

D Grimm, M Egli, M Krüger, S Riwaldt… - Stem Cells and …, 2018 - liebertpub.com
Experimental cell research studying three-dimensional (3D) tissues in space and on Earth
using new techniques to simulate microgravity is currently a hot topic in Gravitational Biology …

Biomanufacturing of 3D tissue constructs in microgravity and their applications in human pathophysiological studies

Z Ren, AD Harriot, DB Mair, MK Chung… - Advanced …, 2023 - Wiley Online Library
The growing interest in bioengineering in‐vivo‐like 3D functional tissues has led to novel
approaches to the biomanufacturing process as well as expanded applications for these …

Biosensor integrated tissue chips and their applications on Earth and in space

A Yau, Z Wang, N Ponthempilly, Y Zhang… - Biosensors and …, 2023 - Elsevier
The development of space exploration technologies has positively impacted everyday life on
Earth in terms of communication, environmental, social, and economic perspectives. The …