Understanding the mechanism by which patterned gene activity leads to mechanical
deformation of cells and tissues to create complex forms is a major challenge for …

The development of fluorescent labels and powerful imaging technologies in the last two
decades has revolutionized the field of fluorescence microscopy, which is now widely used …

Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the
accuracy of translation, yet the physiological consequence of having fewer protein synthesis …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

Ribosomes are multicomponent molecular machines that synthesize all of the proteins of
living cells. Most of the genes that encode the protein components of ribosomes are …

Many adult tissues and organs including the intestine rely on resident stem cells to maintain
homeostasis and regeneration. In mammals, the progenies of intestinal stem cells (ISCs) …

Mosaic analysis with double markers (MADM) offers one approach to visualize and
concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM …

Precise, repeatable genetic access to specific neurons via GAL4/UAS and related methods
is a key advantage of Drosophila neuroscience. Neuronal targeting is typically documented …

We generated two new genetic tools to efficiently tag genes in Drosophila. The first, Double
Header (DH) utilizes intronic MiMIC/CRIMIC insertions to generate artificial exons for GFP …

The Drosophila larva has been used to investigate many processes in cell biology, including
morphogenesis, physiology and responses to drugs and new therapeutic compounds …