Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …

Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …

The metalloproteinases degrade extracellular matrix (ECM) components and activate growth
factors, thereby contributing to physiological events (tissue remodeling in pregnancy, wound …

The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes
were originally described as cleaving extracellular matrix (ECM) substrates with a …

The 92-kDa type IV collagenase (MMP-9) plays a critical role in tissue remodeling. We
undertook a study to determine whether the KiSS-1 gene, previously shown to suppress …

Overexpression of the transcription factor Snail in epithelial MDCK cells promotes the
epithelial-mesenchymal transition (EMT) and the acquisition of an invasive phenotype. We …

The expression of metastasis‐associated protein 1 (MTA1) correlates well with tumor
metastases; however, the associated molecular mechanism is not fully understood. Here, we …

Activating transcription factor 3 (ATF3) is rapidly induced by diverse environmental insults
including genotoxic stress. We report herein that its interaction with p53, enhanced by …

Significant progress has been made in the clinical management of a variety of
cardiovascular diseases. Nevertheless, the therapeutic efficacy of the current treatment …

Histone modifications are associated with distinct transcription states and serve as heritable
epigenetic markers for chromatin structure and function. While H3 K9 methylation defines …