A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

In late 2012 it was evidenced that most of the human genome is transcribed but only a small
percentage of the transcripts are translated. This observation supported the importance of …

Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of lung cancer
and there have been few therapeutic alternatives for recurrent LUSC due to the lack of …

High-throughput RNA sequencing unveiled the complexity of transcriptome and significantly
increased the records of long noncoding RNAs (lncRNAs), which were reported to …

STUDY QUESTION How does the human oocyte transcriptome change with age and
ovarian reserve? SUMMARY ANSWER Specific sets of human oocyte messenger RNAs …

Transcriptome analyses using high-throughput methodologies allow a deeper
understanding of biological functions in different cell types/tissues. The present study …

Objective: Advances in genomics and molecular biology have led to the discovery of a large
group of uncharacterized long noncoding RNAs (lncRNAs). Emerging evidence indicated …

Not that long ago, the human genome was discovered to be mainly non-coding, that is
comprised of DNA sequences that do not code for proteins. The initial paradigm that non …

Long non-coding RNA (lncRNA) is a group of RNAs with broad biogenesis, which are longer
than 200 nt and highly conserved in their secondary and tertiary structures. lncRNA that …

The fusion of two highly differentiated cells, an oocyte with a spermatozoon, gives rise to the
zygote, a single totipotent cell, which has the capability to develop into a complete, fully …