Advances in bladder cancer biology and therapy
The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …
generation sequencing has identified the genes most mutated in bladder cancer. This …
TERT—regulation and roles in cancer formation
M Dratwa, B Wysoczańska, P Łacina, T Kubik… - Frontiers in …, 2020 - frontiersin.org
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …
complex plays a key role in cancer formation by telomere dependent or independent …
m5C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 …
N Wang, R Chen, M Deng, W Wei, Z Zhou, K Ning… - Cell Death & …, 2023 - nature.com
The significance of 5-methylcytosine (m5C) methylation in human malignancies has become
an increasing focus of investigation. Here, we show that m5C regulators including writers …
an increasing focus of investigation. Here, we show that m5C regulators including writers …
Biomarkers for bladder cancer diagnosis and surveillance: a comprehensive review
Bladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise
in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is …
in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is …
Telomerase regulation: a role for epigenetics
F Dogan, NR Forsyth - Cancers, 2021 - mdpi.com
Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …
Tieing together loose ends: telomere instability in cancer and aging
G Borges, M Criqui, L Harrington - Molecular oncology, 2022 - Wiley Online Library
Telomere maintenance is essential for maintaining genome integrity in both normal and
cancer cells. Without functional telomeres, chromosomes lose their protective structure and …
cancer cells. Without functional telomeres, chromosomes lose their protective structure and …
DNA methylation of the TERT promoter and its impact on human cancer
Telomere maintenance is a hallmark of human cancer that enables replicative immortality.
Most cancer cells acquire telomere maintenance by telomerase activation through …
Most cancer cells acquire telomere maintenance by telomerase activation through …
Validation of a novel, sensitive, and specific urine-based test for recurrence surveillance of patients with non-muscle-invasive bladder cancer in a comprehensive …
Bladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth
most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70–75% will …
most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70–75% will …
Biological and clinical perspectives of TERT promoter mutation detection on bladder cancer diagnosis and management
The telomerase reverse transcriptase (TERT) promoter mutations are associated with
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer
JD Apolónio, JS Dias, MT Fernandes, M Komosa… - Clinical …, 2022 - Springer
Background Breast cancer (BC) is the most frequently diagnosed cancer and a leading
cause of death among women worldwide. Early BC is potentially curable, but the mortality …
cause of death among women worldwide. Early BC is potentially curable, but the mortality …