[HTML][HTML] HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies
Y Zhao, C Xing, Y Deng, C Ye, H Peng - Genes & Diseases, 2024 - Elsevier
The hypoxic microenvironment is an essential characteristic of most malignant tumors.
Notably, hypoxia-inducible factor-1 alpha (HIF-1α) is a key regulatory factor of cellular …
Notably, hypoxia-inducible factor-1 alpha (HIF-1α) is a key regulatory factor of cellular …
Glutor, a glucose transporter inhibitor, exerts antineoplastic action on tumor cells of thymic origin: Implication of modulated metabolism, survival, oxidative stress …
Neoplastic cells overexpress glucose transporters (GLUT), particularly GLUT1 and GLUT3,
to support altered metabolism. Hence, novel strategies are being explored to effectively …
to support altered metabolism. Hence, novel strategies are being explored to effectively …
Blockade of phosphodiesterase 5 by sildenafil reduces tumor growth and potentiates tumor‐killing ability of cisplatin in vivo against T cell lymphoma: Implication of …
In the past years, PDE5 has emerged as a promising therapeutic target for many cancers
due to its highly upregulated expression. Interestingly, a recent in vitro study by our group …
due to its highly upregulated expression. Interestingly, a recent in vitro study by our group …
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-associated death in the West. This type of cancer has a very poor prognosis notably …
G Yang, Y Hori, A Couvineau - … mitochondrial dynamics and …, 2023 - books.google.com
Pancreatic cancers widely represented (> 90%) by pancreatic ductal adenocarcinoma
(PDAC) are the most lethal human digestive cancer with a very poor 5-year-survival rate …
(PDAC) are the most lethal human digestive cancer with a very poor 5-year-survival rate …