Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells
differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age …

Many forms of blindness result from the dysfunction or loss of retinal photoreceptors.
Induced pluripotent stem cells (iPSCs) hold great potential for the modelling of these …

Age-related macular degeneration (AMD) causes severe visual impairment due in part to
age-dependent impairment of retinal pigment epithelium (RPE). It has been suggested that …

The retinal degenerative diseases, which together constitute a leading cause of hereditary
blindness worldwide, are largely untreatable. Development of reliable methods to culture …

In this article, we show that mouse embryonic stem cell-or induced pluripotent stem cell-
derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete …

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy.
We previously demonstrated retinal repair and restoration of vision through transplantation …

Human pluripotent stem cells have the potential to provide comprehensive model systems
for the earliest stages of human ontogenesis. To serve in this capacity, these cells must …